Welcome to peptiCKDdb!

Peptide and protein-centric database integrating manually curated, high-throughput peptidomics and proteomics data retrieved from state-of-the-art literature related to chronic kidney disease (CKD).

PMID Method # of peptides Biomarker Disease Source Comments Validation (Y/N)
18004714 CE-MS 1 IgA nephropathy (IgAN) urine Renal damage model Y
18004714 CE-MS 21 IgA nephropathy (IgAN) urine Renal damage model Y
18448586 CE-MS 32 Diabetic nephropathy (DN) urine DN detection Y
19012428 CE-MS 8 CKD Chronic kidney disease (CKD) urine Amplitude Calibration CKD Marker N
19225019 CE-MS 9 Renal Fanconi syndrome (FS) urine Diagnosis of FS Y
19296547 CE-MS 34 Aging biomarkers Aging urine Urinary proteome profile of human kidney aging N
19340089 CE-MS 38 ADPKD model Autosomal dominant polycystic kidney disease (ADPKD) urine ADPK model Y
19564150 CE-MS 58 Antibody-associated vasculitis (AAV) urine AAV bomarker Y
19643930 LC-MALDI-TOF MS 6 ESRD Diabetic nephropathy (DN) urine Biomarkers for progressive renal function decline N
19902551 MALDI-TOF-MS 14 IgA nephropathy (IgAN) blood IgAN biomarker model N
20150539 LC-MALDI MS/MS 63 AR Acute renal allograft rejection (AR) urine Renal allograft rejection Y
20616184 CE-MS 272 CKD Chronic kidney disease (CKD) urine CKD prediction and progression Y
20827258 CE-MS 20 AKI Acute kidney injury (AKI) urine AKI prediction Y
20975990 CE-MS 34 DN model Diabetic nephropathy (DN) urine Detection of DN Y
21040538 CE-MS 18 CKD-273 Diabetic nephropathy (DN) urine Renoprotective treatment (Irbesartan) N
21698285 CE-MS 49 Fabry disease (FD) urine Prinary biomarker pattern of female FD Y
22399069 MALDI-TOF MS 6 Glomerular kidney disease (GKD) urine GKD detection Y
22842158 CE-MS/MALDI 12 MALDI Chronic kidney disease (CKD) urine CE-MS and MALDI comparison N
22842158 CE-MS/MALDI 10 CEMS Chronic kidney disease (CKD) urine CE-MS and MALDI comparison N
22872235 CE-MS 32 CKD-273 Diabetic nephropathy (DN) urine DN prediction Y
22872235 CE-MS 63 CKD-273 Diabetic nephropathy (DN) urine DN prediction Y
23086559 CE-MS 14 Diabetic nephropathy (DN) urine Albuminuria progression model Y
23086559 CE-MS 41 Diabetic nephropathy (DN) urine Albuminuria progression model Y
23326375 CE-MS 57 ADPKD_142 Autosomal dominant polycystic kidney disease (ADPKD) urine ADPKD diagnosis Y
23466993 LC-MALDI-TOF MS 4 Diabetic nephropathy (DN) blood Biomarkers of renal function decline in diabetes type 1 Y
23946195 CE-MS 20 12PUV End-stage renal disease (ESRD) urine Peptidomic prediction of postnatal renal function Y
24498182 MALDI-TOF MS 8 Idiopatic nephrotic syndrome (INS) urine MCS vs. FSGS classification Y
24498182 MALDI-TOF MS 9 Idiopatic nephrotic syndrome (INS) urine MCS vs. FSGS classification Y
24589724 CE-MS 67 CKD-273 Diabetic nephropathy (DN) urine Early DN detection Y
25515948 CE-MS 22 Chronic kidney disease (CKD) urine Post-liver transplantation CKD N
25589610 CE-MS 67 CKD-273 Chronic kidney disease (CKD) urine CKD prediction and progression Y
PMID Method # of proteins Disease Source Comments Validation (Y/N)
15984045 2D-DIGE 1 Diabetic nephropathy (DN) urine DN prediction
16372274 MALDI-TOF MS 80 Glomerulonephritis (GN) urine Poor 2DE-gels quality
17095863 Antibody Array 20 Chronic kidney disease (CKD) urine CKD initiation and progression
17242005 LC-MS/MS 10 IgA nephropathy (IgAN) urine IgAN biomarker
17269729 ESI-Q-TOF MS/MS 18 Diabetic nephropathy (DN) blood DN diagnosis
17327332 LC-MS 11 Diabetic nephropathy (DN) urine Urinary biomarkers of DN
17327332 LC-MS 7 Diabetic nephropathy (DN) urine Urinary biomarkers of DN
17616539 SELDI-TOF MS & nano-LC-MS/MS 8 Mild ischaemic kidney injury urine Early renal injury detection
17634209 SELDI-TOF-MS 3 Diabetic nephropathy (DN) urine DN detection
18095357 nano-HPLC-ESI-MS/MS 8 Glomerulonephritis (GN) urine Clinical response biomarkers in IgAN
19177158 LC-MS/MS 12 Dense Deposit Disease (DDD) kidney Glomerular components of DDD
19177462 MALDI-TOF-MS 12 Diabetic nephropathy (DN) urine DN detection
19218887 SELDI-TOF MS; MALDI-TOF/TOF MS 4 Lupus nephritis (LN) urine Biomarker panel for active pediatric LN
19887787 MALDI-TOF MS 2 Contrast-induced nephropathy (CIN) urine CIN prediction
20093355 MS/MS; LTQ LX linear ion trap 356 Interstitial fibrosis and tubular atrophy (IFTA) kidney IFTA mechanism
20176211 MALDI-MS/MS 4 Acute kidney injury (AKI) urine Early AKI predicton
20411046 LC-MS/MS 127 Autosomal dominant polycystic kidney disease (ADPKD) kidney Characterization of the renal cyst fluid proteome
20599305 SELDI-TOF MS 3 Acute kidney injury (AKI) urine Early AKI predicton
20671095 SELDI-TOF MS 1 Diabetic nephropathy (DN) urine DN diagnosis
21136688 ESI-Q-TOF MS/MS 10 Diabetic nephropathy (DN) blood DN detection
21136911 LC-MS/MS 39 Autosomal dominant polycystic kidney disease (ADPKD) kidney Phosphoproteins in ADPKD
21137083 LC-MS/MS 22 Diabetic nephropathy (DN) blood DN prediction
21137087 MALDI-TOF-MS 2 Diabetic nephropathy (DN) blood DN detection
21165148 CE-MS/MS 11 Chronic kidney disease (CKD) blood CKD progression
21183621 ProtoArray 37 Chronic kidney disease (CKD) blood Novel autoantibodies in CKD
21569504 MALDI-TOF MS 5 Chronic kidney disease (CKD) blood Mechanism of CKD- and CVD-related atherosclerosis
21569504 MALDI-TOF MS 9 Chronic kidney disease (CKD) blood Mechanism of CKD- and CVD-related atherosclerosis
21569504 MALDI-TOF MS 3 Chronic kidney disease (CKD) blood Mechanism of CKD- and CVD-related atherosclerosis
21595033 LC-MS/MS 124 Glomerulonephritis (GN) urine Urinary exosomes in GN
21595033 LC-MS/MS 99 Glomerulonephritis (GN) urine Urinary exosomes in GN
21635978 MALDI-TOF MS 40 Endemic nephropathy (BEN) urine EN detection
21635978 MALDI-TOF MS 40 Endemic nephropathy (BEN) urine EN detection
21659735 MALDI-TOF MS 30 Diabetic nephropathy (DN) kidney Pathogenesis of DN
22083613 LC-MS/MS 17 Lupus nephritis (LN) kidney LN biomarker
22172726 QSTAR Elite LC-MS/MS 99 Diabetic nephropathy (DN) kidney Protein expression in diabetic glomeruli
22211921 MALDI-TOF-TOF MS 2 Diabetic nephropathy (DN) urine Normo-albuminuric DN detection
22282304 LC-MS/MS 15 Diabetic nephropathy (DN) kidney Proteomic analysis of glomeruli
22282304 LC-MS/MS 14 Diabetic nephropathy (DN) kidney Proteomic analysis of glomeruli
22282304 LC-MS/MS 15 Diabetic nephropathy (DN) kidney Proteomic analysis of glomeruli
22282304 LC-MS/MS 30 Diabetic nephropathy (DN) kidney Proteomic analysis of glomeruli
22498882 ESI-Q-TOF MS/MS 16 Lupus nephritis (LN) urine Biomarker of active LN
22536212 LC-MS/MS 195 Diabetic nephropathy (DN) urine Detection of DN
22641580 ESI-Q-TOF MS/MS 19 Mesangial proliferative glomerulonephritis (MePGN) kidney Proteome profiles of MePGN
22718539 ESI-Q-TOF MS/MS 35 Autosomal recessive polycystic kidney disease (ARPKD) kidney ARPKD progression mechanism
22759352 MALDI-TOF-MS/MS 1 Idiopatic nephrotic syndrome (INS) blood Steroid therapy efficacy biomarker
22792249 LC-MALDI-TOF MS 10 End-stage renal disease (ESRD) blood Prognostic biomarkers in hemodialysis
22792249 LC-MALDI-TOF MS 9 End-stage renal disease (ESRD) blood Prognostic biomarkers in hemodialysis
22814359 MALDI-TOF/TOF-MS 5 Chronic kidney disease (CKD) blood Erythrocyte membrane proteins in CKD
22814359 MALDI-TOF/TOF-MS 2 Chronic kidney disease (CKD) blood Erythrocyte membrane proteins in CKD
22891811 LC-MS/MS 21 Congenital bilateral hydronephrosis (CH) urine Urinary biomarkers of CH
22891811 LC-MS/MS 21 Congenital bilateral hydronephrosis (CH) urine Urinary biomarkers of CH
22927352 nano-LC-MS/MS 18 Idiopatic nephrotic syndrome (INS) blood Proteomic profiles in childhood INS
22927352 nano-LC-MS/MS 36 Idiopatic nephrotic syndrome (INS) urine Proteomic profiles in childhood INS
23078846 RP-nano-HPLC-ESI-MS/MS 9 End-stage renal disease (ESRD) peritoneal dialysate Proteomic map of peritoneal dialysate
23143504 LC-MS/MS 30 Acute kidney injury (AKI) urine Detection of AKI after cardiac surgery
23161552 MALDI-TOF/TOF-MS 4 IgA nephropathy (IgAN) urine IgAN biomarker
23205849 MALDI-TOF MS 2 Idiopathic Focal segmental glomerulosclerosis (FSGS) urine FSGS recurrence
23228063 LC-MS/MS 154 Autosomal dominant polycystic kidney disease (ADPKD) urine ADPKD diagnosis
23464927 HPLC-QTOF MS/MS 1 Fabry disease (FD) urine Fabry disease detection and monitoring
23536133 LC-MS/MS 1 Diabetic nephropathy (DN) urine DN detection
23577616 MALDI-TOF MS 6 IgA nephropathy (IgAN) blood Peptide profiles associated with histological lesions in IgAN patients
23577616 MALDI-TOF MS 6 IgA nephropathy (IgAN) urine Peptide profiles associated with histological lesions in IgAN patients
23599406 MALDI-TOF-MS/MS 2 IgA nephropathy (IgAN) urine IgAN biomarker
23708385 ProteinChip SELDI 1 IgA nephropathy (IgAN) blood IgAN biomarker
23762862 LC-MS/MS 10 Chronic glomerulonephritis (CGN) peritoneal dialysate Peritoneal dialysate of chronic glomerulonephritis
23781506 ESI-MS/MS 10 Diabetic nephropathy (DN) peritoneal dialysate Peritoneal dialysate of diabetes mellitus
24067438 LC-ESI-MS/MS 9 Acute kidney injury (AKI) urine AKI prediction
24211404 LC-MS/MS 24 Diabetic nephropathy (DN) urine DN diagnosis
24339887 nLC-MS/MS & GeLC-MS/MS 18 IgA nephropathy (IgAN) urine IgAN Patient classification
24434790 MALDI-TOF/TOF 19 IgA nephropathy (IgAN) kidney Glomerular protein profiles in IgAN
24790760 nLC-MS/MS 89 Focal segmental glomerulosclerosis (FSGS) urine FSGS diagnosis
24914093 MALDI-TOF-MS 19 Lupus nephritis (LN) kidney Class IV lupus nephritis analysis
24938435 IEF/LC-MS/MS 18 IgA nephropathy (IgAN) urine IgAN diagnosis and monitoring
25032130 nLC-MS/MS 12 Focal segmental glomerulosclerosis (FSGS) urine FSGS diagnosis
25150443 LC-MS 135 Idiopatic nephrotic syndrome (INS) urine Paediatric INS
25182141 nLC-MS/MS 21 Focal segmental glomerulosclerosis (FSGS) urine Steroid responsiveness
25194005 LMD/MS 12 Monoclonal Ig deposition disease kidney Monoclonal Ig deposition disease detection
25205225 nanoLC-MS/MS 149 Obstructive nephropathy/ ureteropelvic junction urine Congenital obstructive nephropathy biomarkers
25205225 nanoLC-MS/MS 56 Obstructive nephropathy/ ureteropelvic junction urine Congenital obstructive nephropathy biomarkers
25205225 nanoLC-MS/MS 16 Obstructive nephropathy/ ureteropelvic junction urine Congenital obstructive nephropathy biomarkers
25279147 MALDI TOF/TOF 24 IgA nephropathy (IgAN) kidney IgAN diagnosis
25365230 nLC-MS/MS 76 Cystinuria urine Cystinuria biomarkers
25475747 MS assay 8 Autosomal dominant polycystic kidney disease (ADPKD) urine Urinary exosomes as PKD biomarkers
25578432 LC-MS/MS 9 Diabetic nephropathy (DN) urine DKD biomarkers
25622820 MALDI-TOF/TOF 10 Chronic kidney disease (CKD) blood CKD progression
25622820 MALDI-TOF/TOF 11 Chronic kidney disease (CKD) blood CKD progression
25622820 MALDI-TOF/TOF 11 Chronic kidney disease (CKD) blood CKD progression
25666440 LC-MS/MS 91 Fabry disease (FD) urine FD diagnosis
25667632 MALDI-TOF/TOF-MS 22 Membranous nephropathy (MN) kidney MN biomarkers
25755179 nano-HPLC-ESI-MS/MS 72 Autosomal dominant polycystic kidney disease (ADPKD) urine Extracellular vesicles (EVs) for ADPKD monitoring
25755179 nano-HPLC-ESI-MS/MS 47 Autosomal dominant polycystic kidney disease (ADPKD) urine Extracellular vesicles (EVs) for ADPKD monitoring
25755179 nano-HPLC-ESI-MS/MS 60 Autosomal dominant polycystic kidney disease (ADPKD) urine Extracellular vesicles (EVs) for ADPKD monitoring
25755179 nano-HPLC-ESI-MS/MS 25 Autosomal dominant polycystic kidney disease (ADPKD) urine Extracellular vesicles (EVs) for ADPKD monitoring
25957429 nLC-MS/MS 45 IgA nephropathy (IgAN) urine IgA nephropathy diagnosis
25973081 MALDI-TOF MS 13 IgA nephropathy (IgAN) urine IgAN progression
26940098 LC-MS/MS 34 Autosomal dominant polycystic kidney disease (ADPKD) urine Disease-associated extracellular vesicles (EVs)
26940098 LC-MS/MS 22 Autosomal dominant polycystic kidney disease (ADPKD) urine Disease-associated extracellular vesicles (EVs)
26940098 LC-MS/MS 29 Autosomal dominant polycystic kidney disease (ADPKD) urine Disease-associated extracellular vesicles (EVs)

Urinary proteome for healthy subjects

Collection of proteins from urinary proteome profiling studies deposited in the database

PMID Method # of identifications Source Comments
12234320 MALDI-TOF-MS 35 urine Proteome map of normal human urine
12234320 MALDI-TOF-MS 13 urine Proteome map of normal human urine
15668994 LC-MS/MS & MALDI-TOF-MS 140 kidney Normal human kidney glomerulus profiling
16316981 LC-MS/MS 222 urine Urinary proteome
16335936 SELDI-TOF MS 381 urine Urinary proteome
16948836 nanoflow LC-MS/MS 944 urine Urinary proteome
17022654 MALDI-TOF MS 394 urine Urinary proteome
17711322 LC-MS/MS 2356 kidney Normal human kidney glomerulus profiling
17723740 LC-MS/MS 103 urine Urinary proteome
19056867 LC-MS/MS 1144 urine Urinary exosomes
23376485 LC-MS/MS 2827 urine Podocyte exosomal proteome
24436468 LC-MS/MS 128 kidney Glomerular ECM proteome
25091982 LC-MS/MS 323 kidney FFPE tissue protein extraction